Technologies Bridging Natural Materials and Products
Plukenesia selects technology platforms to solve practical challenges such as low solubility, instability, limited bioavailability, process constraints, and scale-up requirements. Technology is not the final goal; it is a tool for producing safe, high-quality, beneficial, and manufacturable products.
Lipid-Based Delivery Systems
Nanoemulsions improve the dispersion of lipophilic ingredients, physical stability, and user experience. Critical parameters include globule size, polydispersity index, zeta potential, pH, viscosity, morphology, and stability.
Nanostructured Lipid Carriers and Solid Lipid Nanoparticles protect lipophilic active ingredients, improve dispersion, and enable controlled release. Development covers lipid and surfactant selection, manufacturing methods, characterization, encapsulation efficiency, and scale-up.
Liposomes, Niosomes, and Proniosomes are vesicular systems developed through membrane-component selection, particle-size optimization, encapsulation efficiency, stability, and route-of-administration suitability.
Solubility-Enhancement Technologies
Amorphous Solid Dispersions improve the dispersion and solubility of poorly soluble active ingredients through polymer selection, preparation methods, solid-state characterization, and recrystallization control. Nanocrystals increase surface area and dissolution rate while addressing stabilizers, size distribution, crystallinity, and storage stability.
Process Technologies
Microfluidics supports controlled and reproducible particle or vesicle formation. Ultrasonic extraction and homogenization intensify extraction and reduce particle size while controlling energy, time, temperature, and scale. Freeze-drying helps protect heat-sensitive materials through optimized cryoprotectants, freezing profiles, pressure, temperature, time, residual moisture, and reconstitution. Oil refining and standardization include decolorization, deodorization, adsorption, filtration, antioxidant stabilization, and protective packaging.
Technology Selection Framework
Selection considers the scientific problem and target product; safety of materials and excipients; critical quality attributes and process parameters; reproducibility and validation; equipment and scale-up capability; stability, regulation, cost, and manufacturing feasibility.
Collaboration Opportunities
These platforms support joint research, formulation, optimization, characterization, analytical method development, prototyping, scale-up, technology transfer, and industry co-development.